টিউমার কোষের বিস্তার প্রতিরোধ করবে নতুন আবিষ্কৃত অণু

সম্প্রতি একদল আন্তর্জাতিক বিজ্ঞানী এমন একটি অণু আবিষ্কার করছেন যেটি টিউমার কোষকে প্রাথমিক ক্যান্সার সাইট থেকে শরীরের অন্যান্য জায়গায় ছড়াতে বাঁধা দানে সক্ষম। ইউনিভার্সিটি অফ ইয়র্ক, লাইডেন ইউনিভার্সিটি এবং টেকনিয়নের (ইসরাইল ইনস্টিটিউট অফ টেকনোলোজি) মাল্টিডিসিপ্লিনারি রিসার্চ টিম একটি ক্ষুদ্র, চিনির অণুর সদৃশ অণু আবিষ্কার করতে সক্ষম হয়েছেন। তারা দেখিয়েছেন, এই চিনি-সদৃশ অণু ইঁদুরের শরীরে ক্যান্সার ছড়ানোয় বাঁধা দিতে যথেষ্ট কার্যকর। এই আবিষ্কার ঔষধটির ক্লিনিকাল পরীক্ষায় আরো একধাপ এগিয়ে নিয়ে গেছে।

 

যেভাবে শরীরে ক্যান্সার কোষ প্রবেশ করে

ক্যান্সারকে মারণঘাতী করার জন্য এর পেছনে যেটি কাজ করে সেটি হলো মেটাস্টাসিস। এই মেটাস্টাসিস নির্ভর করে প্রাথমিক টিউমারের স্থান থেকে ক্যান্সার আক্রান্ত কোষের ব্লাড ভেসেল ওয়াল এবং টিস্যু ব্যারিয়ার ভেদ করে এর গ্রোথের সেকেন্ডারি সাইটে পৌঁছানোর ক্ষমতার উপর। এর জন্য প্রয়োজন হয় এনজাইমের যেটি কিনা কোষের আশেপাশের প্রোটিন এবং সুগারকে হজম করে ক্যান্সার সেলকে ওই ফাঁকা জায়গা দিয়ে প্রবেশ করার সুযোগ করে দেয়।

কোষের চারপাশে যে সুগার থাকে তার মধ্যে অধিক পরিমাণে যেটি পাওয়া যায় সেটি হলো হেপারান সালফেট। এটি লম্বা শিকলসদৃশ অণু। এই হেপারান সালফেটকে ডাইজেস্ট করে ফেলে হেপারানেজ নামের এনজাইম। ফলে এর শিকল টুকরো টুকরো হয়ে যায় এবং কোষের আশেপাশের জায়গা দুর্বল হয়ে পড়ে।

 

যেভাবে ক্যান্সার কোষ শনাক্ত করা হয়

মেটাস্টাটিক ক্যান্সার সেল প্রচুর পরিমাণে হেপারানেজ এনজাইম উৎপাদন করে যা পুরো শরীরে এই সেলকে ছড়িয়ে দিতে ভূমিকা রাখে। এন্টি-ক্যান্সার থেরাপির মূল ভিত্তি হচ্ছে এই হেপারানেজকে চিহ্নিত করে ফেলা।

গবেষকগণ তাদের আবিষ্কৃত চিনির মত অণুর সাথে এই হেপারানেজ এনজাইমের বিক্রিয়া ঘটাতে সক্ষম হয়েছেন। যখন বিক্রিয়া নতুন বন্ধন গঠন করে তখন এই হেপারানেজ এনজাইম, হেপারিন সুগার চেইনকে কাটার ক্ষমতা হারিয়ে ফেলে। যার দরুণ, কোষের আশেপাশের টিস্যু ক্যান্সার আক্রান্ত হওয়া থেকে বেঁচে যায়।

ইয়র্কের কেমিস্ট্রি ডিপার্টমেন্টের প্রফেসর, গিডিয়ন ডেভিস এবং ড. লিয়াং উ প্রথমে এই চিনি-সদৃশ অণুর হেপারানেজকে দুর্বল করে দেওয়ার সামগ্রিক প্রক্রিয়া দেখাতে সক্ষম হয়েছেন। বর্তমানে রিসার্চ টিম কাজ করছে কিভাবে এই অণুকে আরো কার্যকরী করে তোলা যায়।

 

গবেষণার আদ্যোপান্ত

প্রফেসর ডেভিড বলেন, “এটা সত্যিই বিস্ময়ের ব্যাপার যে পুরো কাজটাই এনজাইমের ফাংশন এবং স্ট্রাকচারের মৌলিক বিষয়গুলো থেকে থেকে করা হয়েছে।”

টেকনিয়নের গবেষকগণ নতুন এই অণু ইঁদুরের ফুসফুসের ক্যান্সার, স্তন ক্যান্সার এবং ব্লাড ক্যান্সারের ক্ষেত্রে প্রয়োগ করতে সক্ষম হয়েছেন। যদিও এই মুহূর্তে এটি ক্লিনিকাল পরীক্ষার অনুমোদন পাবে কিনা তা বলা দুষ্কর, তবে এতে সন্দেহ নেই, ইঁদুরের ক্ষেত্রে এর ফলাফল যথেষ্ট আশাব্যাঞ্জক। একারণে সংশ্লিষ্ট প্রতিষ্ঠানগুলো ইতোমধ্যেই এই অণুর পেটেন্টের জন্য আবেদন করেছে।

গবেষণার প্রধান, লেইডেন ইউনিভার্সিটির প্রফেসর হারম্যান ওভারক্লিফটের মতে, এখন তাদের দেখতে হবে এই অণু মানুষের শরীরের জনু উপযোগী কি না। এই কাজগুলো করতে লাগবে আরো কয়েক বছর। হয়তো এর ফলাফল হবে সম্পূর্ণ নেগেটিভ, তবুও এই রিস্ক কারো না কারো নিতেই হবে!

গবেষণাপত্র: Casper de Boer et al, Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo, Proceedings of the National Academy of Sciences (2022)

DOI: doi.org/10.1073/pnas.2203167119

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