করোনাভাইরাস ক্ষণে-ক্ষণে ত্বরান্বিত করছে তার বিবর্তনের গতি – নতুন গবেষণায় উঠে এলো চমকপ্রদ তথ্য!

ডোহার্টি ইনস্টিটিউটের নেতৃত্বে নতুন এক গবেষণায় পাওয়া গেছে যে কোভিট-১৯ এর জন্য দায়ী SARS-CoV-2 ভাইরাসটি ক্ষণিকের জন্য তার বিবর্তনীয় গতিকে ত্বরান্বিত করার ক্ষমতা রাখে, যা অন্যান্য ভাইরাসের তুলনায় আরও দ্রুত নতুন ভ্যারিয়েন্ট আবির্ভাব ঘটাতে সক্ষম।

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সম্প্রতি Molecular Biology and Evolution জার্নালে প্রকাশিত হয় গবেষণাপত্রটি। ডোহার্টি ইনস্টিটিউটের অস্ট্রেলিয়ান রিসার্চ কাউন্সিল ডিইসিআরএ রিসার্চ ফেলো এবং মেলবোর্ন ইউনিভার্সিটির ডক্টর সেবাস্টিয়ান ডুচেনের নেতৃত্বে এক গবেষক দল COVID-19 রোগের জন্য দায়ী SARS-CoV-2 ভাইরাসের মধ্যে এক অদ্ভুত ব্যাপার লক্ষ্য করে। তারা দেখতে পান ভাইরাসটি মাঝে মাঝে স্বল্পস্থায়ী মিউটেশনাল বিস্ফোরণের মধ্য দিয়ে যায় এবং তারপরে তার আবার মিউটেশনের ‘স্বাভাবিক’ হারে ফিরে আসে।

সাধারণত সব ভাইরাসই মোটামুটি একটি ধ্রুবক হারে বিবর্তীত হয়, বেশিরভাগ ভাইরাসেরই একটি নতুন ভ্যারিয়েন্ট বিকাশ করতে এক বছর বা তারও বেশি সময় নেয়।  

ড. ডুচেন বলেন, “গবেষণায় আমরা খেয়াল করেছি যে, SARS-CoV-2 ভাইরাসটি স্বাভাবিক ভাইরাসের বিবর্তনগত গতিতে চেয়ে অনেক বেশি মিউটেশনের মধ্য দিয়ে গেছে। উদাহরণস্বরূপ, ডেল্টা ভ্যারিয়েন্টটি মাত্র ছয় সপ্তাহের মধ্যে আবির্ভূত হয়েছিল।

কেন এত দ্রুত বিবর্তন ঘটছে তা বোঝার জন্য, ড. ডুচেনের পরীক্ষাগার SARS-CoV-2 ভাইরাসের স্ট্রেন থেকে শত-শত জিনোম সিকোয়েন্সের গণনামূলক বিশ্লেষণ পরিচালনা করেন। এই প্রক্রিয়াগুলির অধীনে ভাইরাসের বিভিন্ন রূপ বা ভারিয়েন্ট কীভাবে উদ্ভূত হয় তা বোঝার জন্য, প্রথম চারটির অর্থাৎ আলফা, বিটা, গামা এবং ডেল্টা ভ্যারিয়েন্টের উপর ফোকাস রাখা হয়।  

করোভাইরাসের প্রতিনিধি চিত্র। ছবি: IANS
করোভাইরাসের প্রতিনিধি চিত্র।
ছবি: IANS

প্রাথমিকভাবে ধরা হয়েছিল যে SARS-CoV-2 ভাইরাস তার বিবর্তনের হার বাড়িয়েছে, কিন্তু আরো বিশ্লেষণে দেখে গিয়েছে যে এটি আসলে মিউটেশনের ক্ষমতা সাময়িকভাবে বাড়াতে পারে যা। অনেকটা থেকে থেকে গাড়ির এক্সিলেটরে জোরে চাপ দেয়ার মতো।

ড. ডুচেন বলেন, মিউটেশনের এই “গতি বৃদ্ধি”র বেশ কিছু কারণ থাকতে পারে। এর মধ্যে অধিক মানুষদের মধ্যে দীর্ঘস্থায়ী সংক্রমণ, শক্তিশালী প্রাকৃতিক নির্বাচন, টিকাবিহীন জনসংখ্যার মধ্যমে ভাইরাসটি দ্রুত ছড়িয়ে পড়ার ফলে বেশি মিউটেশনের সুযোগ অন্যতম।

এই কারণে ড. ডুচেন টিকা বাড়ানোর প্রয়োজনীয়তার উপরও জোর দেন।  অধিক মানুষ টিকা কার্যক্রমের অন্তর্ভুক্ত হলে ভাইরাস সংক্রমণের সুযোগ কম পাবে।

গবেষণাপত্র: The Emergence of SARS-CoV-2 Variants of Concern Is Driven by Acceleration of the Substitution RateMolecular Biology and Evolution (2022).

DOI: 10.1093/molbev/msac013

Source: The Peter Doherty Institute for Infection and Immunity

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