খাওয়া জীবনের অন্যতম বড় আনন্দের কাজ 😋। এতে যে কত্ত আনন্দ তা বোঝাতে হবে না কাউকে। কিন্তু অতিরিক্ত খাওয়া জীবনের সমস্যাগুলির মধ্যে একটি।
২০১৯ সালে, ওয়াশিংটন স্কুল অফ মেডিসিনের ইউনিভার্সিটির স্টুবার ল্যাবের গবেষকরা আবিষ্কার করে যে খাবার সময় মোটা ইঁদুরের দেহের নির্দিষ্ট কিছু কোষ এক্টিভ হয় এবং তৃপ্তি, বা ‘পেট ভরে গেছে’ অনুভূতি নির্দেশকারী সংকেতগুলি প্রতিরোধ করে। এখন এই কোষগুলি কী ভূমিকা পালন করে তার একটি গভীর পর্যবেক্ষণ করা হয়েছে সম্প্রতি প্রকাশিত একটি গবেষণাতে।
Neuron জার্নালে ৭ই অক্টোবর প্রকাশিত একটি গবেষণার ফলাফলে ইঁদুরের গ্লুটামেটারজিক নিউরন (glutamatergic neuron)-র কার্যকারিতা সম্পর্কে রিপোর্ট করা হয়েছে। এই কোষগুলি মূলত মস্তিষ্কের পার্শ্বীয় হাইপোথ্যালামিক এলাকায় অবস্থিত একটি হাব যা খাওয়ানো সহ অনুপ্রাণিত আচরণগুলিকে নিয়ন্ত্রণ করে।
গবেষকরা দেখেছেন যে এই নিউরন কোষগুলি মস্তিষ্কের দুটি ভিন্ন অঞ্চলের মধ্যে যোগাযোগ করে: পার্শ্বীয় হাবেনুলা (যেটা ডিপ্রেশন প্যাথোফিজিওলজির একটি প্রধান অঞ্চল) এবং ভেন্ট্রাল টেগমেন্টাল এলাকা (যেটা মোটিভেশন, রিওয়ার্ড এবং আসক্তি নিয়ন্ত্রণে প্রধান ভূমিকা পালন করে)
অধ্যাপক স্টুবার বলেন, “আমরা দেখেছি যে এই কোষগুলি কোনোধরনের মনোলিথিক গ্রুপ নয়, এবং এই কোষগুলির বিভিন্ন স্বাদের ক্ষেত্রে বিভিন্নভাবে কাজ করে।” তিনি ইউডব্লিউ সেন্টার ফর দ্য নিউরোবায়োলজি অব অ্যাডিকশন, পেইন অ্যান্ড ইমোশনে কাজ করেন এবং এই গবেষণাপত্রের সিনিয়র লেখক।
গবেষণাটির ফলে ইটিং ডিসঅর্ডারের সাথে সম্পর্কযুক্ত মস্তিষ্কের সার্কিটগুলি সম্পর্কে জানার আরেক ধাপ এগিয়ে গেলো। এতে করে ইটিং ডিসঅর্ডারের কার্যকরি চিকিৎসার বের করার আরো একধাপ সহজ হয়ে গেলো।
দি স্টুবার ল্যাব মস্তিষ্কের রিওয়ার্ড সিস্টেমের প্রধান সেল গ্রুপের কাজ অধ্যয়ন করেছে, এবং আসক্তি ও মানসিক অসুস্থতায় তাদের ভূমিকা চিহ্নিত করেছে – কাজটি মুলত চিকিৎসা খোঁজার আশায়। এখন প্রশ্ন হল এই কোষগুলিকে মস্তিষ্কের অন্যান্য অংশের ক্ষতি না করে ওষুধ দ্বারা টার্গেট করা যায় কিনা।
তাদের সাম্প্রতিক গবেষনা পদ্ধতিগতভাবে পার্শ্বীয় হাইপোথ্যালামিক গ্লুটামেট নিউরন বিশ্লেষণ করেছে। তো হাইপোথ্যালামিক গ্লুটামেট নিউরন বিশ্লেষণ কালে গবেষকরা দেখেন যে, যখন ইঁদুরকে খাওয়ানো হচ্ছে, তখন পাশের হাবেনুলার নিউরনগুলি, ভেন্ট্রাল টেগমেন্টাল এলাকার তুলনায় বেশি প্রতিক্রিয়াশীল। যা নির্দেশ করে যে এই নিউরনগুলি খাবার খাওয়া নিয়ন্ত্রণে আরও বড় ভূমিকা পালন করতে পারে।
গবেষকরা আমরা কীভাবে খাই তার উপর লেপটিন এবং ঘ্রেলিন হরমোনের প্রভাবের দিকেও নজর দিয়েছিলেন। লেপটিন এবং ঘ্রেলিন উভয়ই মেসোলিম্বিক ডোপামাইন সিস্টেমে তাদের প্রভাবের মাধ্যমে আচরণ নিয়ন্ত্রণ করে বলে মনে করা হয়, যা মস্তিষ্কের রিওয়ার্স সিস্টেমের মূল উপাদান। কিন্তু এই হরমোনগুলি মস্তিষ্কের পার্শ্বীয় হাইপোথ্যালামিক এলাকায় নিউরনগুলিকে কীভাবে প্রভাবিত করে সে সম্পর্কে খুব কমই জানা গেছে। গবেষকরা দেখেছেন যে লেপটিন নিউরনের ক্রিয়াকলাপকে নিঃশেষ করে দেয় যা পাশের হাবেনুলায় প্রজেক্ট করে এবং নিউরনের কার্যকলাপ বৃদ্ধি করে যেটা আবার ভেন্ট্রাল টেগমেন্টাল এলাকায় প্রজেক্ট করে। কিন্তু এদিকে ঘ্রেলিন এর বিপরীত কাজ করে।
এই গবেষণায় ইঙ্গিত দেওয়া হয়েছে যে মস্তিষ্কের সার্কিটগুলি খাওয়াকে নিয়ন্ত্রণ করে তা অন্তত আংশিকভাবে মাদকাসক্তির সাথে জড়িত মস্তিষ্কের সার্কিটারের সাথে ওভারল্যাপ করে। তাতে অতিরিক্ত খাওয়ার জন্য তৈরি সংকেত অনেকটা নেশা করার আগ্রহ তৈরির সংকেতের সাথে সম্পর্কযুক্ত।
গবেষণায় স্থূলতা (যাকে বিশ্ব স্বাস্থ্য সংস্থা বৈশ্বিক মহামারী বলে থাকে)-র ক্ষেত্রে মস্তিষ্কের ভূমিকা নিয়েও গবেষণা যোগ করা হয়েছে।
গবেষনাপত্র: Transcriptional and functional divergence in lateral hypothalamic glutamate neurons projecting to the lateral habenula and ventral tegmental area, Neuron (2021).
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