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ওয়াল্টার রিডের তৈরি Spike Ferritin Nanoparticle COVID-19 ভ্যাক্সিন, সংক্ষেপে SpFN ইতিবাচক ফলাফলের সাথে এই বছরের শুরুতে এনিমেল ট্রায়াল সম্পন্ন করেছে।
ফেইজ ১ এর হিউম্যান ট্রায়াল শুরু হয় এপ্রিল মাসে, শেষ হবে মাসেই এবং প্রাথমিক ফলাফল বেশ চমৎকার। যদিও এখনও ফেইজ ১ এর চূড়ান্ত পর্যালোচনা চলছে। এই নতুন ভ্যাকসিনের এখনও ফেইজ ২ এবং ফেইজ ৩ ট্রায়ালের মধ্য দিয়ে যেতে হবে। তবে ওয়াল্টার রিডের সংক্রামক রোগ শাখার পরিচালক ডা. কায়ভন মোডজারাদ এর মতে সেই ফেইজও সাফল্যের সঙ্গে কৃতকার্য হবে বলে আশা করা হচ্ছে।
সম্প্রতি প্রকাশিত বেশি কিছু প্রাক-ক্লিনিকাল স্টাডির ফলাফল দেখায় যে ওয়াল্টার রিড আর্মি ইনস্টিটিউট অফ রিসার্চ (WRAIR)-এর গবেষকদের দ্বারা তৈরি এই Spike Ferritin Nanoparticle (SpFN) কোভিড-১৯ ভ্যাকসিন শুধুমাত্র একটি শক্তিশালী রোগ প্রতিরোধ ক্ষমতা তৈরি করে না বরং এটি SARS-CoV-2 সহ অনান্য জাতের করোনাভাইরেসের বিরুদ্ধে ব্যাপক সুরক্ষা প্রদান করতে পারে।
১৬ই ডিসেম্বর সায়েন্স ট্রান্সলেশনাল মেডিসিন জার্নালে প্রকাশিত প্রাক-ক্লিনিক্যাল গবেষণায় দেখা যায় যে SpFN ভ্যাকসিন SARS-CoV-2 এর মূল স্ট্রেন দ্বারা সৃষ্ট রোগ থেকে নন-জিউম্যান প্রাইমেটদের রক্ষা করে এবং প্রধান SARS-CoV-2 ভ্যারিয়েন্ট এবং ২০০২ সালে সালে উদ্ভূত SARS-CoV-1 ভাইরাসের বিরুদ্ধে অত্যন্ত শক্তিশালী এবং ‘broadly-neutralizing’ অ্যান্টিবডি প্রতিক্রিয়া তৈরি করে। এখন ফেইজ ১ এর হিউম্যান ট্রায়ালে তো ভাল ফলাফল দেখা গেছে। আশা করা যাচ্ছে এখনকার ভ্যাক্সিনের ‘কর্মক্ষমতা’ নিয়ে তোলা প্রশ্নকে পিষে ফেলবে নতুন এই “সর্বকাজে পারদর্শী” ভ্যাক্সিনটি।
WRAIR একটি সেকেন্ডারি ক্যান্ডিডেট ভ্যাকসিনও তৈরি করেছে, যা একটি SARS-CoV-2 Spike Receptor-Binding Domain Ferritin Nanoparticle ভ্যাকসিন। এই ভ্যাক্সিনটি SpFN ভ্যাকসিনের তুলনায় করোনাভাইরাস স্পাইক প্রোটিনের একটি ছোট অংশকে টার্গেট করে। সম্প্রতি প্রসিডিংস অফ দ্য ন্যাশনাল একাডেমি অফ সায়েন্সেস জার্নালে প্রকাশিত একটি গবেষণার ফলাফল দেখায় যে এই ভ্যাকসিনটি সম্ভাব্যভাবে SARS-CoV-2 ভেরিয়েন্ট এবং SARS-CoV-1 এর বিরুদ্ধে একই রকম সুরক্ষা প্রদান করে।
WRAIR-এর সংক্রামক রোগ গবেষণা কেন্দ্রের পরিচালক ডা. নেলসন মাইকেল বলেন, “কোভিড-১৯ এর হুমকি দিনদিন বিকশিত হচ্ছে, নতুন নতুন ভ্যারিয়েন্ট দিয়ে হুমকি বাড়িয়েই চলছে এবং হয়তো শেষ পর্যন্ত অন্যান্য উদীয়মান রোগের আরও কঠিন হুমকি মুখে পড়তে পারি। তাই একটি পরবর্তী প্রজন্মের ভ্যাকসিন তৈরিতে আমাদের বিনিয়োগ হল কোভিড-১৯ এবং ভবিষ্যতের রোগের হুমকির দিকে এগিয়ে যাওয়ার জন্য একটি গুরুত্বপূর্ণ পদক্ষেপ।”
গবেষণাপত্রগুলো:
- A SARS-CoV-2 Ferritin Nanoparticle Vaccine Elicits Protective Immune Responses in Nonhuman Primates
- Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques
- SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses
- A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters
- SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity
- SARS-COV-2-Spike-Ferritin-Nanoparticle (SpFN) Vaccine With ALFQ Adjuvant for Prevention of COVID-19 in Healthy Adults, Clinical Trials
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