ছয় মাসের মধ্যে ৪১% কার্যকারিতা হারায় ফাইজারের টিকা

সম্প্রতি প্রকাশিত একটি গবেষণা প্রতিবেদন অনুসারে, ফাইজার-বায়োএনটেকের পূর্ণ দুই ডোজ টিকা (BNT162b2) গ্রহণের ছয় মাসের মধ্যেই টিকার কার্যকারিতা প্রায় অর্ধেকে নেমে আসে। তবে বিজ্ঞানীদের মতে টিকার বুুস্টার ডোজই করোনা ভাইরাসের সংক্রমণ বন্ধ করতে মূল ভুমিকা রাখবে।

৪ অক্টোবর বিশ্ববিখ্যাত ল্যানসেট জার্নালে প্রকাশিত গবেষণাপত্র বলছে, ফাইজার-বায়োনটেকের দুই ডোজ টিকা নিলে ৯০% মানুষ করোনা ভাইরাসে আক্রান্ত হলেও ছয় মাস পর্যন্ত হাসপাতালে ভর্তি হওয়া থেকে রক্ষা পায়। তবে এই সময়ের মধ্যে সকল ধরণের ভ্যারিয়েন্টের বিরুদ্ধেই টিকার কার্যকারিতা ক্রমান্বয়ে হ্রাস পেতে থাকে। এক মাস পর থেকেই ৮৮% কার্যকারিতা কমতে কমতে ছয় মাস পর ৪৭ শতাংশে গিয়ে ঠেকে।

২০২০ সালের ১৪ ডিসেম্বর থেকে ২০২১ সালের ৮ আগস্টের সময়কালে ১২ বছরের বেশি বয়সী চৌত্রিশ লক্ষ ছত্রিশ হাজার নয়শত সাতান্ন জন ব্যক্তির মধ্যে পরীক্ষাটি চালানো হয়। এর মাঝে ১৭৯৯৩৯৫ জন মহিলা এবং ১৬৩৭৩৯৪ জন পুরুষ ছিল। এই সময়ের এক বছর পূর্বে ৭৪২৮৪ জন অংশগ্রহণকারীদের কোভিড-১৯ পরীক্ষায় এক বা একাধিক পজিটিভ এবং ৫৪৩৬২৮ জন অংশগ্রহণকারীদের এক বা একাধিক নেগেটিভ ফলাফল ছিল।

কাইসার পারমানেন্টে সাউদার্ন ক্যালিফোর্নিয়া (Kaiser Permanente Southern California) হেলথকেয়ার থেকে প্রাপ্ত তথ্যের উপর ভিত্তি করে গবেষণাটি পরিচালিত হয়।

গবেষকরা বিশ্লেষণ করে দেখেছেন যে, পরীক্ষা চলাকালীন সময়ে প্রায় তিন মিলিয়ন মানুষের ৫.৪% কোভিড-১৯ এ আক্রান্ত হয়েছিলেন এবং তার মধ্যে ৬.৬% রোগীদের হাসপাতালে ভর্তি হতে হয়েছিল।

এক মাসে মধ্যেই ভাইরাসের বিরুদ্ধে টিকার কার্যকারিতা ৪১% কমলেও টিকা যে আক্রান্ত ব্যক্তিদের হাসপাতালমূখী হওয়া থেকে বাঁচিয়েছে, এক্ষেত্রে কোনো সন্দেহ নেই। এই গবেষণায় পাওয়া ফলাফল মার্কিন যুক্তরাষ্ট্রের সেন্টার ফর ডিজিজ কন্ট্রোলের রিপোর্টে সাথেও মিলে যায় যে, টিকার কার্যকারিতা ছয় মাস পর প্রায় অর্ধেকের মতো কমে যায়।

ডেল্টা ভ্যারিয়েন্টের বিপক্ষেও প্রথম মাস শেষে টিকাটি  বেশ কার্যকরী ছিল। কার্যকারিতার হার ছিল ৯৩%। কিন্তু চার মাস শেষে এ হার ৫৩ শতাংশে নেমে আসে। অন্যান্য ভ্যারিয়েন্টের বিপরীতে প্রথম মাস শেষে টিকাটি ৯৭% কার্যকরী থাকলেও একইভাবে চার-পাঁচ মাসের মধ্যে কমে ৬৭ শতাংশে এসে নামে। কাইসার পারমানেন্টে সাউদার্ন ক্যালিফোর্নিয়া ডিপার্টমেন্ট অব রিসার্চ অ্যান্ড এভালুয়েশনের (Kaiser Permanente Southern California Department of Research and Evaluation)কর্মকর্তা এবং এই গবেষণার প্রধান ডক্টর সারা টারটফ বলেন, ‘আমাদের গবেষণা নিশ্চিত করে যে টিকা মহামারি নিয়ন্ত্রণে একটি গুরুত্বপূর্ণ হাতিয়ার এবং এটি ডেল্টসহ অন্যান্য ভ্যারিয়েন্টের বিরুদ্ধে জটিল রোগ ও হাসপাতালে ভর্তি প্রতিরোধে অত্যন্ত কার্যকরী।’

ফাইজার ভ্যাক্সিনের সিনিয়র ভাইস প্রেসিডেন্ট ও প্রধান চিকিৎসা কর্মকর্তা ডক্টর লুইস জোদার বলেন, ‘আমাদের ভ্যারিয়েন্ট-নির্দিষ্ট বিশ্লেষণ দেখায় যে ফাইজার-বায়োনটেকের টিকা (BNT162b2) ডেল্টাসহ সকল ভ্যারিয়েন্টের বিরুদ্ধে কার্যকরী।’অন্যদিকে লন্ডন কিংস কলেজের ফার্মাসিকিউটাল মেডিসিনের ভিসিটিং প্রফেসর, ডক্টর পেনি ওয়ার্ড, যিনি এই গবেষণায় যুক্ত ছিলেন না; তিনি বলেন, ‘এই প্রকাশনা মার্কিন যুক্তরাষ্ট্রের বাস্তব প্রমাণের উপর ভিত্তি করে ফাইজার-বায়োনটেকের টিকার কার্যকারিতা বর্ণনা করে।’

গবেষণাপত্র: Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study, The Lancet (2019)

DOI: 10.1016/S0140-6736(21)02183-8

Source: The Guardian

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